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More serious but less common risks can include: Gallbladder disease Pancreatitis Worsening of diabetic retinopathy in patients with diabetes Thyroid C-cell tumors observed in animal studies Certain conditions, medications, or risk factors may influence whether a healthcare provider thinks GLP-1s are appropriate for you, so women should review their full medical history with a qualified provider before starting therapy

A health care provider must document that the patient met the appropriate requirements when GLP-1 therapy began

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The investigators compared people who had used these drugs with clinically similar patients who had not received them, then assessed whether either group was more or less likely to develop substance use disorders